Quick answer

If it is your first trip and you want the easiest sightseeing start, choose Sultanahmet. If you want a better evening base, choose Galata/Karakoy/Beyoglu. If food and local neighborhoods matter more than old-city convenience, choose Kadikoy.

Choosing without overthinking

For a first Istanbul trip, do not chase a perfect center. Pick the tradeoff you actually want. Sultanahmet saves energy for monuments. Galata, Karakoy, and Beyoglu make evenings easier. Kadikoy gives a stronger food-and-neighborhood feel.

If your flight arrives late or you travel with heavy luggage, compare airport access before locking the hotel.

Planning Choices

Easy monuments
Sultanahmet. Best if you want to walk early to classic sights.
Evenings and variety
Galata/Karakoy/Beyoglu. Often the most flexible first-time compromise.
Repeat-feeling first trip
Kadikoy. Great food, less central for classic sights.